Self-Liganded SuzukiMiyaura Coupling for Site-Selective Protein PEGylation

被引：89

作者：

Dumas, Anaelle ^{[1
]}

Spicer, Christopher D. ^{[1
]}

Gao, Zhanghua ^{[1
]}

Takehana, Tsuyoshi

Lin, Yuya A. ^{[1
]}

Yasukohchi, Tohru

Davis, Benjamin G. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 14期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会; 瑞士国家科学基金会;

关键词：

catalysis; PEGylation; proteins; Suzuki-Miyaura coupling; PALLADIUM NANOPARTICLES; SUZUKI; ARYL; CHEMISTRY; DESIGN; WATER;

D O I：

10.1002/anie.201208626

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Building with PEGs: PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3916 / 3921

页数：6

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