A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP+-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains

被引：40

作者：

Naoi, M

Maruyama, W

Matsubara, K

Hashizume, Y

机构：

[1] NATL INST LONGEV SCI,DEPT BASIC GERONTOL,BIOCHEM & METAB LAB,OBU 474,JAPAN

[2] ASAHIKAWA MED COLL,DEPT PHARM,ASAHIKAWA,HOKKAIDO 078,JAPAN

[3] AICHI MED UNIV,INST MED SCI AGING,NAGAKUTE,AICHI 48011,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 235卷 / 1-2期

关键词：

Parkinson's disease; neurotoxin; N-Methyltransferase; N-Methy[(R)salsolinol; 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion; dopamine; nigro-striatum;

D O I：

10.1016/S0304-3940(97)00723-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An endogenous MPTP-like dopaminergic neurotoxin, N-methyl(R)salsolinol, increases in the parkinsonian cerebrospinal fluid and accumulates in the human nigro-striatum. An N-methyltransferase specific for (R)salsolinol was found in human brain with optimal pH at 7.0 and 8.5. The correlation of the enzyme activity with the level of N-methyl(R)salsolinol and its oxidation product, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion was examined in the brain regions. Neutral N-methyltransferase activity in the striatum was found to correlate with the level of the endogenous MPP+-like isoquinolinium ion in the substantia nigra (P < 0.001). Considering that this neutral N-methyltransferase activity increases in parkinsonian lymphocytes, the enzyme may be an endogenous factor in the pathogenesis of Parkinson's disease. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：81 / 84

页数：4

共 18 条

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