Lighting up biochemiluminescence by the surface self-assembly of DNA-hemin complexes

被引：158

作者：

Yi, X

Pavlov, V

Gill, R

Bourenko, T

Willner, I ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Farkas Ctr Light Induced Proc, IL-91904 Jerusalem, Israel

来源：

CHEMBIOCHEM | 2004年 / 5卷 / 03期

关键词：

biocatalysis; DNA; hemin; luminescence; monolayers; self-assembly;

D O I：

10.1002/cbic.200300794

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Illuminating DNA: The assembly of two tailored nucleic acids (colored blue and brown in the scheme) in the presence of hemin yields a G-quadruplex that exhibits peroxidase-like activity and catalyzes the generation of chemiluminescence in the presence of H2O2 and luminol. The DNAzyme is employed for the analysis of DNA (green) in solution and on surfaces.

引用

页码：374 / 379

页数：6

共 22 条

[1] In vitro selection of catalytic polynucleotides [J].