Different TNFα expression elicited by glucose in monocytes from type 2 diabetes mellitus patients

被引：16

作者：

Chacon, M. R. ^{[2
]}

Vendrell, J. ^{[2
]}

Miranda, M. ^{[2
]}

Ceperuelo-Mallafre, V. ^{[2
]}

Megia, A. ^{[2
]}

Gutierrrez, C. ^{[2
]}

Fernandez-Real, J. M. ^{[1
,2
]}

Richart, C. ^{[2
]}

Garcia-Espana, A. ^{[2
]}

机构：

[1] Univ Hosp Josep Trueta Girona, Endocrinol & Diabet Unit, Girona, Spain

[2] Hosp Univ Joan XXIII Tarragona, Pere Virgili Inst, Res Dept, Endocrinol & Diabet Unit, Tarragona 43007, Spain

来源：

ATHEROSCLEROSIS | 2007年 / 194卷 / 02期

关键词：

TNF alpha; TNFR1; TNFR2; Type-2; diabetes; Monocytes; Glucose;

D O I：

10.1016/j.atherosclerosis.2006.12.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Increased plasma concentrations of tumor necrosis factor alpha (TNF alpha) system components appear in type 2 diabetes patients with poor glycemic control. We have analyzed the expression of TNF alpha, TNFR1 and TNFR2 when monocytes and lymphocytes isolated from a group of recent onset type 2 diabetic patients, with fasting glucose levels below 7.0mM and glycated haemoglobin (Hb1Ac) in the normal range, were stimulated with high glucose or LPS endotoxin. We report, that cultured monocytes from these type 2 diabetic patients, in comparison to monocytes from non-diabetic individuals, had an enhanced response to LPS but did not respond to an acute glucose challenge (p < 0.05). No differences were observed in the cultured lymphocyte fractions. These results indicate the existence of differences, elicited by LPS or high glucose related stimulus, between monocytes isolated from non-diabetic subjects or from type 2 diabetes patients. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E18 / E25

页数：8

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