Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis

被引：74

作者：

Pradhan, S ^{[1
]}

Gupta, RP ^{[1
]}

Shashank, S ^{[1
]}

Pandey, N ^{[1
]}

机构：

[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Neurol, Lucknow 226014, Uttar Pradesh, India

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1999年 / 165卷 / 01期

关键词：

intravenous immunoglobulins; treatment; acute disseminated encephalomyelitis; IVIg; ADEM; demyelination;

D O I：

10.1016/S0022-510X(99)00072-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We describe 4 patients with acute disseminated encephalomyelitis (ADEM) who were treated with intravenous immunoglobulins (IVIg) after getting no immediate response from a 3-5 day course of high dose intravenous methylprednisolone. All had clinical features to suggest poor prognosis and MRI findings to indicate extensive white matter changes in the brain. Two patients who had spinal cord involvement as well, required ventilatory support during acute phase of the illness. All the 4 patients recovered dramatically. Recovery pattern suggested that IVIg might be useful in fulminant ADEM. Further trials are needed to look for the efficacy of IVIg alone and in combination with methylprednisolone in the treatment of ADEM. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：56 / 61

页数：6

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