Linkage disequilibrium of HLA-A11 and A1 with one of the polymorphisms of the gamma-aminobutyric acid receptor type B

被引：1

作者：

Anaya, M

Romero, T

Sofia, RD

Yunis, EJ

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Wallace Labs, Cranbury, NJ USA

来源：

TISSUE ANTIGENS | 2001年 / 58卷 / 05期

关键词：

GABA(B) receptor 1; HLA; linkage disequilibrium;

D O I：

10.1034/j.1399-0039.2001.580506.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The gamma-aminobutyric acid receptor type B 1 (GABA(B) R1) is located approximately at 200 kb telomeric to HLA-A on chromosome 6. It has 11 single-nucleotide polymorphisms (SNPs). We studied the most common of its SNPs (T1974C) in a panel of 118 normal Caucasians from New England and 161 epileptic patients of Caucasian ancestry residing in USA. The frequency of the polymorphism did not differ between patients and controls. Here, we report that the allele C of this SNP in the GABAB R1 gene is in linkage disequilibrium with HLA-A11 (P<0.00001) and to a lesser extent with HLA-A1 (P<0.01).

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收藏

页码：324 / 328

页数：5

相关论文

共 13 条

[1] The metabotropic GABA receptor: molecular insights and their functional consequences [J].

Blein, S ;

Hawrot, E ;

Barlow, P .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (04) :635-650

[2] QUANTITATIVE TRAIT LOCUS FOR READING-DISABILITY ON CHROMOSOME-6 [J].

CARDON, LR ;

SMITH, SD ;

FULKER, DW ;

KIMBERLING, WJ ;

PENNINGTON, BF ;

DEFRIES, JC .

SCIENCE, 1994, 266 (5183) :276-279

[3] Genetic epidemiology of single-nucleotide polymorphisms [J].

Collins, A ;

Lonjou, C ;

Morton, NE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15173-15177

[4] GABAB receptor:: A new paradigm in G protein signaling [J].

Couve, A ;

Moss, SJ ;

Pangalos, MN .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 16 (04) :296-312

[5]

DUBEY DP, 1992, MANUAL CLIN LAB IMMU, P869

[6] Human gamma-aminobutyric acid B receptor gene: Complementary DNA cloning, expression, chromosomal location, and genomic organization [J].

Goei, VL ;

Choi, J ;

Ahn, J ;

Bowlus, CL ;

Raha-Chowdhury, R ;

Gruen, JR .

BIOLOGICAL PSYCHIATRY, 1998, 44 (08) :659-666

[7] GABA (γ-amino-butyric acid) neurotransmission:: Identification and fine mapping of the human GABAB receptor gene [J].

Grifa, A ;

Totaro, A ;

Rommens, JM ;

Carella, M ;

Roetto, A ;

Borgato, L ;

Zelante, L ;

Gasparini, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 250 (02) :240-245

[8]

Hisama F M, 2001, Hum Mutat, V17, P349, DOI 10.1002/humu.34

[9] Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors [J].

Kaupmann, K ;

Huggel, K ;

Heid, J ;

Flor, PJ ;

Bischoff, S ;

Mickel, SJ ;

McMaster, G ;

Angst, C ;

Bittiger, H ;

Froestl, W ;

Bettler, B .

NATURE, 1997, 386 (6622) :239-246

[10] GABA(B) RECEPTORS [J].

KERR, DIB ;

ONG, J .

PHARMACOLOGY & THERAPEUTICS, 1995, 67 (02) :187-246