Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice

被引：22

作者：

Brion, LP

Cammer, W

Satlin, LM

Suarez, C

Zavilowitz, BJ

Schuster, VL

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT MED, BRONX, NY 10461 USA

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT NEUROL, BRONX, NY 10461 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 1997年 / 273卷 / 02期

关键词：

carbonic anhydrase isozymes I; II; III; and IV; carbonic anhydrase II deficiency; hydratase activity; cortex; outer medulla; liver; lung; affinity chromatography; renal tubular acidosis; regulation;

D O I：

10.1152/ajprenal.1997.273.2.F234

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Chronic metabolic acidosis (CMA) in the rabbit upregulates carbonic anhydrase (CA) TV in the proximal convoluted tubule (PCT). This study was designed to assess CA IV expression in a model of CMA in the mouse, i.e., congenital deficiency in CA II [CA(II)D]. In female CA(II)D mice, CA IV specific activity but not CA TV immunoreactivity was upregulated in the renal cortex, specifically in microdissected PCTs. Western blot analysis showed higher expression of CA IV immunoreactive protein in renal membranes from males than in those from females.

引用

页码：F234 / F245

页数：12

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