Activation of in vivo Kupffer cell function by oral administration of Cordyceps sinensis in rats

被引：36

作者：

Nakamura, K

Yamaguchi, Y

Kagota, S

Shinozuka, K

Kunitomo, M

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan

[2] Mukogawa Womens Univ, Interdisciplinary Res Inst Biosci, Nishinomiya, Hyogo 6638179, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1999年 / 79卷 / 04期

关键词：

water extract of Cordyceps sinensis (WECS); Kupffer cell function; colloidal carbon;

D O I：

10.1254/jjp.79.505

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.

引用

收藏

页码：505 / 508

页数：4

相关论文

共 16 条

[1]

VITAMIN-A OR ZYMOSAN PRETREATMENT ATTENUATES ALPHA-NAPHTHYLISOTHIOCYANATE-INDUCED LIVER-INJURY [J].

BAILIE, MB ;

JEAN, PA ;

LAPPIN, PB ;

SCOZZARO, MJ ;

SCHMIDT, TM ;

MOULIN, FJM ;

ROTH, RA .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1995, 134 (01) :63-70

[2]

Role of kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liver [J].

Bayon, LG ;

Izquierdo, MA ;

Sirovich, I ;

VanRooijen, N ;

Beelen, RHJ ;

Meijer, S .

HEPATOLOGY, 1996, 23 (05) :1224-1231

[3]

CHEN GZ, 1991, CHINESE MED J-PEKING, V104, P4

[4]

A NEW METHOD TO MONITOR KUPFFER-CELL FUNCTION CONTINUOUSLY IN THE PERFUSED-RAT-LIVER - DISSOCIATION OF GLYCOGENOLYSIS FROM PARTICLE PHAGOCYTOSIS [J].

COWPER, KB ;

CURRIN, RT ;

DAWSON, TL ;

LINDERT, KA ;

LEMASTERS, JJ ;

THURMAN, RG .

BIOCHEMICAL JOURNAL, 1990, 266 (01) :141-147

[5]

COMPARATIVE-STUDY OF CYTO-TOXICITY, TUMOR NECROSIS FACTOR, AND PROSTAGLANDIN RELEASE AFTER STIMULATION OF RAT KUPFFER CELLS, MURINE KUPFFER CELLS, AND MURINE INFLAMMATORY LIVER MACROPHAGES [J].

DECKER, T ;

LOHMANNMATTHES, ML ;

KARCK, U ;

PETERS, T ;

DECKER, K .

JOURNAL OF LEUKOCYTE BIOLOGY, 1989, 45 (02) :139-146

[6]

LIU P, 1996, CHINA J CHIN MAT MED, V21, P367

[7]

Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse [J].

Manabe, N ;

Sugimoto, M ;

Azuma, Y ;

Taketomo, N ;

Yamashita, A ;

Tsuboi, H ;

Tsunoo, A ;

Kinjo, N ;

NianLai, H ;

Miyamoto, H .

JAPANESE JOURNAL OF PHARMACOLOGY, 1996, 70 (01) :85-88

[8]

Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice [J].

Nakamura, K ;

Yamaguchi, Y ;

Kagota, S ;

Kwon, YM ;

Shinozuka, K ;

Kunitomo, M .

JAPANESE JOURNAL OF PHARMACOLOGY, 1999, 79 (03) :335-341

[9]

Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat [J].

Sauer, JM ;

Waalkes, MP ;

Hooser, SB ;

Kuester, RK ;

McQueen, CA ;

Sipes, IG .

TOXICOLOGY, 1997, 121 (02) :155-164

[10]

Wang SM, 1998, J CELL BIOCHEM, V69, P483, DOI 10.1002/(SICI)1097-4644(19980615)69:4<483::AID-JCB9>3.0.CO