Combination of 5-flucytosine and capsule-binding monoclonal antibody in the treatment of murine Cryptococcus neoformans infections and in vitro

被引：21

作者：

Feldmesser, M

Mukherjee, J

Casadevall, A

机构：

[1] ALBERT EINSTEIN COLL MED, DIV INFECT DIS, DEPT MED, BRONX, NY 10461 USA

[2] ALBERT EINSTEIN COLL MED, DEPT CELL BIOL, BRONX, NY 10461 USA

[3] ALBERT EINSTEIN COLL MED, DEPT MICROBIOL & IMMUNOL, BRONX, NY 10461 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1996年 / 37卷 / 03期

关键词：

D O I：

10.1093/jac/37.3.617

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The efficacy of combination therapy with 5-flucytosine and an IgG1 monoclonal antibody to Cryptococcus neoformans capsular glucuronoxylomannan was studied in vitro with J774.16 murine macrophage-like cells and in vivo in murine cryptococcal infection. The combination of 5-flucytosine and IgG1 was more effective in reducing the numbers of C. neoformans colony-forming units in vitro and in vivo than either agent alone.

引用

页码：617 / 622

页数：6

共 10 条

[1] BLOCK ER, 1973, P SOC EXP BIOL MED, V142, P476, DOI 10.3181/00379727-142-37049
[2] ANTIBODIES ELICITED BY A CRYPTOCOCCUS-NEOFORMANS TETANUS TOXOID CONJUGATE VACCINE HAVE THE SAME SPECIFICITY AS THOSE ELICITED IN INFECTION
CASADEVALL, A
MUKHERJEE, J
DEVI, SJN
SCHNEERSON, R
ROBBINS, JB
SCHARFF, MD
[J]. JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (06) : 1086 - 1093
[3] CRYPTOCOCCUS-NEOFORMANS SEROTYPE-A GLUCURONOXYLOMANNAN-PROTEIN CONJUGATE VACCINES - SYNTHESIS, CHARACTERIZATION, AND IMMUNOGENICITY
DEVI, SJN
SCHNEERSON, R
EGAN, W
ULRICH, TJ
BRYLA, D
ROBBINS, JB
BENNETT, JE
[J]. INFECTION AND IMMUNITY, 1991, 59 (10) : 3700 - 3707
[4] IMPROVED AMPHOTERICIN-B ACTIVITY BY A MONOCLONAL ANTI-CRYPTOCOCCUS-NEOFORMANS ANTIBODY - STUDY DURING MURINE CRYPTOCOCCOSIS AND MECHANISMS OF ACTION
DROMER, F
CHARREIRE, J
[J]. JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (05) : 1114 - 1120
[5] EVOLVING ROLE OF FLUCYTOSINE IN IMMUNOCOMPROMISED PATIENTS - NEW INSIGHTS INTO SAFETY, PHARMACOKINETICS, AND ANTIFUNGAL THERAPY
FRANCIS, P
WALSH, TJ
[J]. CLINICAL INFECTIOUS DISEASES, 1992, 15 (06) : 1003 - 1018
[6] FLUCONAZOLE COMBINED WITH FLUCYTOSINE FOR TREATMENT OF CRYPTOCOCCAL MENINGITIS IN PATIENTS WITH AIDS
LARSEN, RA
BOZZETTE, SA
JONES, BE
HAGHIGHAT, D
LEAL, MA
FORTHAL, D
BAUER, M
TILLES, JG
MCCUTCHAN, JA
LEEDOM, JM
[J]. CLINICAL INFECTIOUS DISEASES, 1994, 19 (04) : 741 - 745
[7] A RAPID FLUORESCENT ASSAY TO DISTINGUISH ATTACHED FROM PHAGOCYTIZED YEAST PARTICLES
LEVITZ, SM
DIBENEDETTO, DJ
DIAMOND, RD
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 101 (01) : 37 - 42
[8] THERAPEUTIC EFFICACY OF MONOCLONAL-ANTIBODIES TO CRYPTOCOCCUS-NEOFORMANS GLUCURONOXYLOMANNAN ALONE AND IN COMBINATION WITH AMPHOTERICIN-B
MUKHERJEE, J
ZUCKIER, LS
SCHARFF, MD
CASADEVALL, A
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (03) : 580 - 587
[9] MONOCLONAL-ANTIBODIES TO CRYPTOCOCCUS-NEOFORMANS CAPSULAR POLYSACCHARIDE MODIFY THE COURSE OF INTRAVENOUS INFECTION IN MICE
MUKHERJEE, S
LEE, SH
MUKHERJEE, J
SCHARFF, MD
CASADEVALL, A
[J]. INFECTION AND IMMUNITY, 1994, 62 (03) : 1079 - 1088
[10] RALPH P, 1975, J IMMUNOL, V114, P898

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