Neutrophil extracellular traps in sterile inflammation: the story after dying?

被引：30

作者：

Cui, Bei-Bei ^{[1
]}

Tan, Chun-Yu ^{[1
]}

Schorn, Christine ^{[2
]}

Tang, Hong-Hu ^{[1
]}

Liu, Yi ^{[1
]}

Zhao, Yi ^{[1
]}

机构：

[1] Sichuan Univ, W China Hosp, Dept Rheumatol & Immunol, Chengdu 610041, Sichuan Provinc, Peoples R China

[2] Univ Erlangen Nurnberg, Dept Internal Med 3, D-91054 Erlangen, Germany

来源：

AUTOIMMUNITY | 2012年 / 45卷 / 08期

关键词：

Neutrophils; dendritic cells; autoimmune disease; adaptive immunity; damage associated molecular patterns; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CELLS; INNATE; ANTIBODIES; ACTIVATE; MYELOPEROXIDASE; DEGRADATION; VASCULITIS; NEPHRITIS; REMNANTS;

D O I：

10.3109/08916934.2012.719952

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Evidences accumulated that the death of neutrophils are not the end of their missions. The neutrophil extracellular traps (NETs), web-like structure, formed after neutrophils dying contribute greatly to immune defense, in both innate and adaptive immunity. Interestingly, previous studies revealed that the generation and activation of NETs do not only rely on bacteria induction, but also in patients with sterile inflammatory diseases, implying an undeniable correlation between NETs and these diseases. This review summarized the latest findings that the crucial roles of NETs in sterile inflammatory diseases, as well as novel targeted therapy based on these new discoveries.

引用

页码：593 / 596

页数：4

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