Decreasing systemic toxicity via transdermal delivery of anticancer drugs

被引：22

作者：

Fang, Jia-You ^{[2
]}

Liu, Pei-Feng ^{[1
,3
]}

Huang, Chun-Ming ^{[1
,3
,4
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Dermatol, San Diego, CA 92161 USA

[2] Chang Gung Univ, Grad Inst Nat Prod, Pharmaceut Lab, Tao Yuan, Taiwan

[3] VA San Diego Healthcare Ctr, San Diego, CA USA

[4] Univ Calif San Diego, Moores Canc Ctr, San Diego, CA 92103 USA

来源：

CURRENT DRUG METABOLISM | 2008年 / 9卷 / 07期

基金：

美国国家卫生研究院;

关键词：

toxicity; transdermal delivery; laser; anticancer drugs;

D O I：

10.2174/138920008785821693

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

When used at a high dose, many anticancer drugs produce undesirable side effects including hepatotoxicity. Transdermal delivery bypasses first-pass metabolism, allowing the use of a lower dose of drug while decreasing systemic toxicity. In this review, we summarize various advanced technologies for improving anticancer drug delivery via the skin. This technology is discussed in the context of three anticancer drugs, 5-fluorouracil (5-FU), methotrexate (MTX) and 5-aminolevulinic acid (5-ALA). The use of a erbium: YAG ( Er: YAG) laser for transdermal delivery of anticancer drugs is specifically highlighted in this review.

引用

收藏

页码：592 / 597

页数：6

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