No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

被引：53

作者：

MacLeod, MJ

Dahiyat, MT

Cumming, A

Meiklejohn, D

Shaw, D

St Clair, D

机构：

[1] Univ Aberdeen, Dept Med & Therapeut, Aberdeen AB9 1FX, Scotland

[2] Univ Aberdeen, Dept Mol & Cell Biol, Aberdeen AB9 1FX, Scotland

来源：

NEUROLOGY | 1999年 / 53卷 / 02期

关键词：

D O I：

10.1212/WNL.53.2.418

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.

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页码：418 / 420

页数：3

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