Transient expression of FGF-5 mRNA in the rat cerebellar cortex during post-natal development

被引：16

作者：

Hattori, Y

Miyake, A

Mikami, T

Ohta, M

Itoh, N

机构：

[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM GENET,SAKYO KU,KYOTO 60601,JAPAN

[2] NATL UTANO HOSP,CLIN RES CTR,KYOTO 616,JAPAN

来源：

MOLECULAR BRAIN RESEARCH | 1997年 / 47卷 / 1-2期

关键词：

fibroblast growth factor; rat; brain; cerebellum; granule cell; development;

D O I：

10.1016/S0169-328X(97)00065-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previously, we showed that fibroblast growth factor (FGF) receptor-4 mRNA was transiently expressed in proliferative granule cells of the external granule layer of the rat cerebellar cortex during early post-natal development (A. Miyake rt al., Mol. Brain Res., 31 (1995) 95-100). In this study, we examined the expression of FGF-5 mRNA in the rat brain during post-natal development by in situ hybridization. FGF-5 mRNA was transiently expressed in granule cells of the internal granule layer of the cerebellar cortex during early post-natal development. The temporal sequence of FGF-5 mRNA expression was similar to that of FGFR-4 mRNA expression. As the proliferation of granule cells in the external granule layer and their migration through the molecular layer into the internal granule layer actively occur during these periods, the present findings suggest that FGF-5 as well as FGFR-4 might play important roles in the proliferation and/or migration of granule cells during the post-natal development of the cerebellar cortex.

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收藏

页码：262 / 266

页数：5

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