The implication of topology for protein structure and aggregation

被引:3
作者
Bohr, J [1 ]
Bohr, HG [1 ]
机构
[1] TECH UNIV DENMARK,CTR BIOL SEQUENCE ANAL,DK-2800 LYNGBY,DENMARK
来源
ZEITSCHRIFT FUR PHYSIK D-ATOMS MOLECULES AND CLUSTERS | 1997年 / 40卷 / 1-4期
关键词
D O I
10.1007/s004600050190
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
For proteins, it is discussed which intrinsic dynamical modes can be present when all static forces are screened. Excitations involving a wringing of the polypeptide chain around its path exists. It is suggested that the existence of such wringons is the underlying cause for the uniqueness of protein folding, and that they may be determinant for aggregation.
引用
收藏
页码:186 / 189
页数:4
相关论文
共 20 条
[1]  
Anfinsen C B, 1975, Adv Protein Chem, V29, P205, DOI 10.1016/S0065-3233(08)60413-1
[2]   UNDERLYING ORDER IN PROTEIN-SEQUENCE ORGANIZATION [J].
BERMAN, AL ;
KOLKER, E ;
TRIFONOV, EN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4044-4047
[3]  
BOHR J, 1995, PROTEIN FOLDS DISTAN
[4]  
BOHR J, 1996, EUROPHYSICS NEWS, V27, P50
[5]  
CHIAVARINI S, 1983, BIOPOLYMERS, V23, P1547
[6]  
Creighton TE, 1993, PROTEINS STRUCTURES
[7]   LINKING NUMBERS AND NUCLEOSOMES [J].
CRICK, FHC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (08) :2639-2643
[8]  
De Gennes P.-G., 1979, SCALING CONCEPTS POL
[9]   TOPOLOGICAL ASPECTS OF THE CONFORMATIONAL TRANSFORMATIONS IN POLYPEPTIDES AND PROTEINS [J].
DESANTIS, P ;
MOROSETTI, S ;
PALLESCHI, A .
BIOPOLYMERS, 1983, 22 (01) :37-42
[10]  
DILL KA, 1995, PROTEIN SCI, V4, P561