Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk?

被引:41
作者
Troisi, Alfonso [1 ]
机构
[1] Univ Roma Tor Vergata, Dept Neurosci, I-00161 Rome, Italy
关键词
Cholesterol; Mental health; Coronary heart disease; Aggression; Suicide; Self-harm; Impulsivity; Negative mood; Postnatal depression; Cognitive dysfunction; LOW SERUM-CHOLESTEROL; CENTRAL SEROTONERGIC ACTIVITY; ESSENTIAL FATTY-ACIDS; LOW HDL CHOLESTEROL; MYOCARDIAL-INFARCTION; DEPRESSIVE SYMPTOMS; CEREBROSPINAL-FLUID; POSTPARTUM PERIOD; MAJOR DEPRESSION; LIPID LEVELS;
D O I
10.1016/j.neubiorev.2008.09.003
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The goal of this article is to review the studies that have linked low cholesterol levels with psychiatric symptoms or behavioral disorders in order to clarify which cholesterol fractions may influence psychological well being and mental health. The distinction between "bad" (i.e., pro-atherogenic) and "good" (i.e., anti-atherogenic) cholesterol is crucial to decide if the clinical benefits of low cholesterol levels for cardiovascular health might turn into a risk factor for psychiatric morbidity. Although the data from studies linking low cholesterol to aggression, suicide and self-harm, impulsivity, negative mood. postnatal depression, and cognitive dysfunction are far from unequivocal, the balance of evidence from new randomized controlled trials is reassuring. However, there are some subgroups of vulnerable individuals who, unlike the majority of persons in the general population, are susceptible to the psychological and behavioral adverse outcomes associated with low cholesterol levels. Because in some cases pro-atherogenic lipid and lipoprotein fractions are involved in this vulnerability, reaching the double goal of promoting both cardiovascular and mental health may be problematic for some individuals. A major task of future research is to identify these vulnerable individuals. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:125 / 132
页数:8
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