Three Dyslexia Susceptibility Genes, DYX1C1, DCDC2, and KIAA0319, Affect Temporo-Parietal White Matter Structure

被引：116

作者：

Darki, Fahimeh ^{[1
]}

Peyrard-Janvid, Myriam ^{[2
]}

Matsson, Hans ^{[2
]}

Kere, Juha ^{[2
,3
,4
]}

Klingberg, Torkel ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, S-17176 Stockholm, Sweden

[2] Karolinska Inst, Dept Biosci & Nutr, Huddinge, Sweden

[3] Karolinska Inst, Sci Life Lab, Solna, Sweden

[4] Univ Helsinki, Haartman Inst, Res Programs Unit, Helsinki, Finland

来源：

BIOLOGICAL PSYCHIATRY | 2012年 / 72卷 / 08期

基金：

瑞典研究理事会;

关键词：

Diffusion tensor imaging; dyslexia genes; general population; reading ability; single nucleotide polymorphism; SNP; DEVELOPMENTAL DYSLEXIA; NEURONAL MIGRATION; READING-DISABILITY; WORKING-MEMORY; CANDIDATE GENE; DISRUPTION; MICROSTRUCTURE; ASSOCIATION; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.biopsych.2012.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown. Methods: We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population. Results: We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability. Conclusions: The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.

引用

页码：671 / 676

页数：6

共 45 条

[1]

[Anonymous], 1998, WOODCOCK READING MAS

[2] Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation [J].

Bates, T. C. ;

Lind, P. A. ;

Luciano, M. ;

Montgomery, G. W. ;

Martin, N. G. ;

Wright, M. J. .

MOLECULAR PSYCHIATRY, 2010, 15 (12) :1190-1196

[3] Imaging brain connectivity in children with diverse reading ability [J].

Beaulieu, C ;

Plewes, C ;

Paulson, LA ;

Roy, D ;

Snook, L ;

Concha, L ;

Phillips, L .

NEUROIMAGE, 2005, 25 (04) :1266-1271

[4] An anatomical signature for literacy [J].

Carreiras, Manuel ;

Seghier, Mohamed L. ;

Baquero, Silvia ;

Estevez, Adelina ;

Lozano, Alfonso ;

Devlin, Joseph T. ;

Price, Cathy J. .

NATURE, 2009, 461 (7266) :983-U245

[5] Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia [J].

Cope, N ;

Harold, D ;

Hill, G ;

Moskvina, V ;

Stevenson, J ;

Holmans, P ;

Owen, MJ ;

O'Donovan, MC ;

Williams, J .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (04) :581-591

[6] No support for association between Dyslexia Susceptibility 1 Candidate 1 and developmental dyslexia [J].

Cope, NA ;

Hill, G ;

van den Bree, M ;

Harold, D ;

Moskvina, V ;

Green, EK ;

Owen, MJ ;

Williams, J ;

O'Donovan, MC .

MOLECULAR PSYCHIATRY, 2005, 10 (03) :237-238

[7] Further evidence for DYX1C1 as a susceptibility factor for dyslexia [J].

Dahdouh, Faten ;

Anthoni, Heidi ;

Tapia-Paez, Isabel ;

Peyrard-Janvid, Myriam ;

Schulte-Koerne, Gerd ;

Warnke, Andreas ;

Remschmidt, Helmut ;

Ziegler, Andreas ;

Kere, Juha ;

Mueller-Myhsok, Bertram ;

Noethen, Markus M. ;

Schumacher, Johannes ;

Zucchelli, Marco .

PSYCHIATRIC GENETICS, 2009, 19 (02) :59-63

[8] Children's reading performance is correlated with white matter structure measured by diffusion tensor imaging [J].

Deutsch, GK ;

Dougherty, RF ;

Bammer, R ;

Siok, WT ;

Gabrieli, JDE ;

Wandell, B .

CORTEX, 2005, 41 (03) :354-363

[9] Influence of the COMT Genotype on Working Memory and Brain Activity Changes During Development [J].

Dumontheil, Iroise ;

Roggeman, Chantal ;

Ziermans, Tim ;

Peyrard-Janvid, Myriam ;

Matsson, Hans ;

Kere, Juha ;

Klingberg, Torkel .

BIOLOGICAL PSYCHIATRY, 2011, 70 (03) :222-229

[10] Progress towards a cellular neurobiology of reading disability [J].

Gabel, Lisa A. ;

Gibson, Christopher J. ;

Gruen, Jeffrey R. ;

LoTurco, Joseph J. .

NEUROBIOLOGY OF DISEASE, 2010, 38 (02) :173-180

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