Recent advances in identifying and validating drug targets in trypanosomes and leishmanias

被引：104

作者：

Barrett, MP ^{[1
]}

Mottram, JC

Coombs, GH

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G11 6NT, Lanark, Scotland

[2] Univ Glasgow, Wellcome Unit Mol Parasitol, Glasgow G11 6NT, Lanark, Scotland

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(98)01433-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive approach, but targets must be selected carefully. Genetic manipulation provides a valuable means of mimicking loss of function attributable to therapeutic intervention, but caution must be exercised when interpreting such data with respect to target validation.

引用

页码：82 / 88

页数：7

共 39 条

[1] The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages
Antoine, JC
Prina, E
Lang, T
Courret, N
[J]. TRENDS IN MICROBIOLOGY, 1998, 6 (10) : 392 - 401
[2] Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana
Bart, G
Frame, MJ
Carter, R
Coombs, GH
Mottram, JC
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 88 (1-2) : 53 - 61
[3] Berens Randolph L., 1995, P89, DOI 10.1016/B978-012473345-9/50007-6
[4] Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids:: Pyruvate, phosphate dikinase
Bringaud, F
Baltz, D
Baltz, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) : 7963 - 7968
[5] DOUBLE TARGETED GENE REPLACEMENT FOR CREATING NULL MUTANTS
CRUZ, A
COBURN, CM
BEVERLEY, SM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) : 7170 - 7174
[6] GENE REPLACEMENT IN PARASITIC PROTOZOA
CRUZ, A
BEVERLEY, SM
[J]. NATURE, 1990, 348 (6297) : 171 - 173
[7] CLONING OF AN AVERMECTIN-SENSITIVE GLUTAMATE-GATED CHLORIDE CHANNEL FROM CAENORHABDITIS-ELEGANS
CULLY, DF
VASSILATIS, DK
LIU, KK
PARESS, PS
VANDERPLOEG, LHT
SCHAEFFER, JM
ARENA, JP
[J]. NATURE, 1994, 371 (6499) : 707 - 711
[8] Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
Dumas, C
Ouellette, M
Tovar, J
Cunningham, ML
Fairlamb, AH
Tamar, S
Olivier, M
Papadopoulou, B
[J]. EMBO JOURNAL, 1997, 16 (10) : 2590 - 2598
[9] Prospects for antiparasitic drugs -: The case of Trypanosoma brucei, the causative agent of African sleeping sickness
Eisenthal, R
Cornish-Bowden, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) : 5500 - 5505
[10] Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection
Engel, JC
Doyle, PS
Hsieh, I
McKerrow, JH
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (04) : 725 - 734

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