Mild Cognitive Impairment: Cerebrospinal Fluid Tau Biomarker Pathologic Levels and Longitudinal Changes in White Matter Integrity

被引：41

作者：

Amlien, Inge K. ^{[1
]}

Fjell, Anders M. ^{[1
,3
]}

Walhovd, Kristine B. ^{[1
,3
]}

Selnes, Per ^{[5
]}

Stenset, Vidar ^{[4
,5
]}

Grambaite, Ramune ^{[5
]}

Bjornerud, Atle ^{[2
,7
]}

Due-Tonnessen, Paulina ^{[7
]}

Skinningsrud, Anders ^{[6
]}

Gjerstad, Leif ^{[8
]}

Reinvang, Ivar ^{[1
]}

Fladby, Tormod ^{[5
]}

机构：

[1] Univ Oslo, Dept Psychol, Ctr Study Human Cognit, N-0317 Oslo, Norway

[2] Univ Oslo, Dept Phys, N-0317 Oslo, Norway

[3] Univ Oslo, Ulleval Hosp, Dept Neuropsychol, N-0317 Oslo, Norway

[4] Univ Oslo, Ulleval Hosp, Dept Neurosurg, N-0317 Oslo, Norway

[5] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway

[6] Akershus Univ Hosp, Dept Multidisiplinary Lab Med & Med Biochem, Lorenskog, Norway

[7] Oslo Univ Hosp, Dept Radiol, Rigshosp, Oslo, Norway

[8] Oslo Univ Hosp, Dept Neurol, Rigshosp, Oslo, Norway

来源：

RADIOLOGY | 2013年 / 266卷 / 01期

关键词：

MEMORY NETWORK; DIFFUSION; DEMENTIA; DISEASE;

D O I：

10.1148/radiol.12120319

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: To evaluate the relationship between (a) pathologic levels of cerebrospinal fluid (CSF) total tau as an index of the intensity of ongoing neuronal degeneration and (b) longitudinal changes in white matter (WM) integrity in patients with mild cognitive impairment (MCI). Materials and Methods: Participants gave written informed consent, and the Norwegian committee for medical research ethics approved the study. Thirty patients with MCI and nonpathologic CSF total tau levels, nine patients with MCI and pathologic CSF total tau levels, and 16 age-matched healthy control subjects underwent diffusion-tensor imaging at baseline and after a mean follow-up of 2.6 years +/- 0.54 (standard deviation), with range of 1.58-3.98 years. The effect of diagnosis (MCI vs no MCI) at baseline and CSF tau levels at fractional anisotropy (FA), mean diffusivity, radial diffusivity (D R), and axial diffusivity were tested with tract-based spatial statistics. Differences in WM integrity at baseline and follow-up and change over time were compared among patients with pathologic CSF total tau levels (MCI high tau), patients with normal CSF total tau levels (MCI low tau), and healthy control subjects. Linear mixed-model between-group within-subject analyses were conducted to examine differences in rate of change over time in FA and D R. Results: Longitudinal analysis of regional WM change revealed significant decrease in FA (P = .038) and increase in D R (P = .018) in the MCI high-tau group relative to control subjects. For D R, the changes were regionally specific to the right cingulum and the right superior and inferior longitudinal fasciculi. Conclusion: Reduction in WM integrity was greater in patients with MCI who had the most intense neuronal degeneration as indexed by using CSF total tau, suggesting that these patients might represent a subgroup of MCI with more intense WM degeneration who are possibly at greater risk of developing Alzheimer disease. (C)RSNA, 2012

引用

页码：295 / 303

页数：9

共 27 条

[1]

A WHITE MATTER DISORDER IN DEMENTIA OF THE ALZHEIMER TYPE - A PATHOANATOMICAL STUDY [J].