Parallel-compound synthesis: Methodology for accelerating drug discovery

被引：47

作者：

Selway, CN ^{[1
]}

Terrett, NK ^{[1
]}

机构：

[1] PFIZER LTD, CENT RES, DISCOVERY CHEM DEPT, SANDWICH CT13 9NJ, KENT, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 05期

关键词：

D O I：

10.1016/0968-0896(96)00058-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parallel compound synthesis enables large numbers of individual compounds to be prepared simultaneously using semiautomated techniques. This fast and efficient methodology has an important role to play in accelerating lead optimisation and hence the whole drug discovery process. The potential of this strategy to rapidly optimise chemical leads and provide structure-activity relationship (SAR) information was demonstrated in two therapeutic areas, antiviral agents (herpes simplex virus), and neurokinin-2 receptor antagonists. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：645 / 654

页数：10

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