N- and O-linked oligosaccharides of allergenic glycoproteins

被引:95
作者
Fötisch, K [1 ]
Vieths, S [1 ]
机构
[1] Paul Ehrlich Inst, Dept Allergol, D-63225 Langen, Germany
关键词
CCD; IgE reactivity; epitope; prevalence; clinical relevance;
D O I
10.1023/A:1014860030380
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cross-linking of cell-bound IgE on mast cells or basophils by polyvalent antigens causes the release of histamine and other mediators of the allergic response which then lead to the development of allergic symptoms. In this event not only peptide epitopes, but also carbohydrates can act as cross-linking elements. Since peptide epitopes of allergens are subject of most published studies, this review is focused on glycosidic epitopes. The current knowledge of the structures and possible epitopes of oligosaccharides linked to allergenic glycoproteins is briefly reviewed, showing that complex plant N-glycans containing alpha1,3 fucose and beta1,2 xylose are most frequently involved in the structures of IgE epitopes. In own studies a prevalence of up to 29% anti-glycan IgE was determined among pollen-allergic patients. The clinical relevance of these carbohydrate specific IgE antibodies is still a matter of controversial discussions.
引用
收藏
页码:373 / 390
页数:18
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