Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices

被引：70

作者：

Kumar, KM ^{[1
]}

Shah, MH ^{[1
]}

Ketkar, A ^{[1
]}

Mahadik, KR ^{[1
]}

Paradkar, A ^{[1
]}

机构：

[1] Bharati Vidyapeeth Deemed Univ, Poona Coll Pharm, Dept Pharmaceut, Pune 411038, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2004年 / 272卷 / 1-2期

关键词：

glyceryl monooleate; diazepam; chlorpheniramine maleate; liquid crystalline phases; floating matrices;

D O I：

10.1016/j.ijpharm.2003.12.025

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Glycerol monooleate (GMO) matrix was found to be a gastro-retentive carrier system suitable for both polar and as well as non-polar drugs. Chlorpheniramine maleate (CPM) and diazepam (DZP) were used as model drugs. Effect of PEG 4000, PEG 10000, and stearic acid on floatability and release profile was studied. Water uptake increased with increase in the loading of polar drug (CPM) and decreased with non-polar drug (DZP). Similar effect was found to occur in case of drug release. PEGs increased the release up to certain concentration and decreased thereafter. Drug release decreased linearly with concentration of stearic acid. The type and extent of mesophases formed were significantly affected by the nature of drug, excipients and their concentration. Thus the selection of suitable excipients depending on polarity of drug, could help to modulate the floatability and release profile from GMO matrices. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：151 / 160

页数：10

共 15 条

[1]

THE RELEASE OF DRUGS FROM MONOGLYCERIDE-WATER LIQUID-CRYSTALLINE PHASES [J].