Tertiary structure prediction of SARS coronavirus helicase

被引：24

作者：

Bernini, A

Spiga, O

Venditti, V

Prischi, F

Bracci, L

Huang, JD

Tanner, JA

Niccolai, N

机构：

[1] Univ Siena, Dept Biol Mol, Biomol Struct Res Ctr, I-53100 Siena, Italy

[2] SienaBiografix Srl, Siena, Italy

[3] Univ Hong Kong, Dept Biochem, Hong Kong, Hong Kong, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 343卷 / 04期

关键词：

SARS coronavirus; protein structure; structure prediction; molecular modeling; helicase structure; drug design;

D O I：

10.1016/j.bbrc.2006.03.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and Peculiar proteins which have been proposed as Suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1101 / 1104

页数：4

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