Novel Faces of Heme Oxygenase-1: Mechanisms and Therapeutic Potentials

被引：23

作者：

Dulak, Jozef ^{[1
]}

Jozkowicz, Alicja ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Med Biotechnol, Fac Biochem Biophys & Biotechnol, PL-30387 Krakow, Poland

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2014年 / 20卷 / 11期

关键词：

D O I：

10.1089/ars.2013.5761

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Not only double, Janus face, but numerous appearances characterize heme oxygenase-1 (HO-1), an inducible enzyme which main role is to degrade heme. Recently, the noncanonical functions of HO-1 have particularly attracted researchers' attention. Indeed, understanding the enzyme-independent activities of HO-1 can provide additional chances for translational application of research on HO-1. In this Forum, eight reviews and two original articles describe a plethora of mechanisms in which this pleiotropic protein is involved. Further understanding of HO-1 functions is of particular significance for elucidating the pathology of various human diseases and providing rationale for novel therapies. Antioxid. Redox Signal. 20, 1673-1676.

引用

收藏

页码：1673 / 1676

页数：4

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