NGAL-Siderocalin in kidney disease

被引：92

作者：

Paragas, Neal ^{[1
]}

Qiu, Andong ^{[1
]}

Hollmen, Maria ^{[1
]}

Nickolas, Thomas L. ^{[1
]}

Devarajan, Prasad ^{[2
]}

Barasch, Jonathan ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

[2] Cincinnati Childrens Hosp, Cincinnati, OH USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2012年 / 1823卷 / 09期

关键词：

NGAL; Siderocalin; UTI; Acute Kidney Injury; Catechol; Enterochelin; GELATINASE-ASSOCIATED LIPOCALIN; UROPATHOGENIC ESCHERICHIA-COLI; TAMM-HORSFALL PROTEIN; HYDROXYL-RADICAL FORMATION; ACUTE-RENAL-FAILURE; URINARY-TRACT; ANTIMICROBIAL PEPTIDE; HUMAN BETA-DEFENSIN-1; QUANTITATIVE-ANALYSIS; SERUM CREATININE;

D O I：

10.1016/j.bbamcr.2012.06.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Kidney damage induces the expression of a myriad of proteins in the serum and in the urine. The function of these proteins in the sequence of damage and repair is now being studied in genetic models and by novel imaging techniques. One of the most intensely expressed proteins is lipocalin2, also called NGAL or Siderocalin. While this protein has been best studied by clinical scientists, only a few labs study its underlying metabolism and function in tissue damage. Structure-function studies, imaging studies and clinical studies have revealed that NGAL-Siderocalin is an endogenous antimicrobial with iron scavenging activity. This review discusses the "iron problem" of kidney damage, the tight linkage between kidney damage and NGAL-Siderocalin expression and the potential roles that NGAL-Siderocalin may serve in the defense of the urogenital system. This article is part of a Special Issue entitled: Cell Biology of Metals. (C) 2012 Published by Elsevier B.V.

引用

页码：1451 / 1458

页数：8

共 138 条

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Expression of lactoferrin in the kidney:: Implications for innate immunity and iron metabolism [J].