A preliminary study of the analysis of Cannabis by supercritical fluid chromatography with atmospheric pressure chemical ionisation mass spectroscopic detection

被引：28

作者：

Backstrom, B

Cole, MD

Carrott, MJ

Jones, DC

Davidson, G

Coleman, K

机构：

[1] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,FORENS SCI UNIT,GLASGOW G1 1XW,LANARK,SCOTLAND

[2] UNIV NOTTINGHAM,DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

[3] ANACHEM LTD,LUTON LU2 0EB,BEDS,ENGLAND

来源：

SCIENCE & JUSTICE | 1997年 / 37卷 / 02期

关键词：

forensic science; drugs of abuse; supercritical fluid chromatography; atmospheric pressure chemical ionization mass spectroscopy; cannabis; drug identification;

D O I：

10.1016/S1355-0306(97)72153-1

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A rapid method is described for the analysis of Cannabis products by supercritical fluid chromatography (SFC) coupled to atmospheric pressure chemical ionization-mass spectroscopic (APCI-MS) detection. The method had a shorter analysis time than CC-MS methods, without the need for derivatization prior to analysis. It was also faster than HPLC methods, with better resolution and definitive identification. Linearity of detector response to cannabidiol, Delta(8)-tetrahydrocannabinol, Delta(9)-tetrahydrocannabinol and cannabinol was established, the detection limits for mass on column being 0.55ng, 1.20ng, 0.69ng and 2.10ng respectively. The technique offers a means by which Cannabis products can be definitively identified in a single chromatographic run. Application to casework samples is described.

引用

页码：91 / 97

页数：7

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