Mechanisms of action of new antiepileptic drugs

被引：73

作者：

Macdonald, RL

Greenfield, LJ

机构：

[1] UNIV MICHIGAN, MED CTR, DEPT NEUROL, ANN ARBOR, MI 48109 USA

[2] UNIV MICHIGAN, MED CTR, DEPT PHYSIOL, ANN ARBOR, MI 48109 USA

来源：

CURRENT OPINION IN NEUROLOGY | 1997年 / 10卷 / 02期

关键词：

D O I：

10.1097/00019052-199704000-00009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Many new antiepileptic drugs have been developed to treat seizure disorders. The established antiepileptic drugs reduce neuronal excitability by promoting sodium channel inactivation, inhibiting T-type calcium channels, or enhancing gamma-aminobutyric acid type A receptor-mediated inhibition. Several of the newer agents employ similar mechanisms, whereas others may enhance gamma-aminobutyric acid-ergic inhibitory systems or inhibit glutamatergic excitatory neurotransmission, and may be neuroprotective or antiepileptogenic.

引用

页码：121 / 128

页数：8

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