Transcriptional mechanisms regulating myeloid-specific genes

被引:37
作者
Skalnik, DG
机构
[1] Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA
[2] Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA
基金
美国国家卫生研究院;
关键词
granulocyte; macrophage; eosinophil; AML1; CCAAT/enhancer binding protein; PU.1;
D O I
10.1016/S0378-1119(02)00387-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Myeloid blood cells comprise an important component of the immune system. Proper control of both lineage- and stage-specific gene expression is required for normal myeloid cell development and function. In recent years, a relatively small number of critical transcriptional regulators have been identified that serve important roles both in myeloid cell development and regulation of lineage-restricted Gene expression in mature myeloid cells. This review summarizes our current understanding of the regulation of lineage- and stage -restricted transcription during myeloid cell differentiation, how critical transcriptional regulators control myeloid cell development, and how perturbations in transcription factor function results in the development of leukemia. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1 / 21
页数:21
相关论文
共 297 条
[1]  
AHNE B, 1994, J BIOL CHEM, V269, P17794
[2]   CCAAT displacement protein binds to and negatively regulates human papillomavirus type 6 E6, E7, and E1 promoters [J].
Ai, WD ;
Toussaint, E ;
Roman, A .
JOURNAL OF VIROLOGY, 1999, 73 (05) :4220-4229
[3]   A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY [J].
AKIRA, S ;
ISSHIKI, H ;
SUGITA, T ;
TANABE, O ;
KINOSHITA, S ;
NISHIO, Y ;
NAKAJIMA, T ;
HIRANO, T ;
KISHIMOTO, T .
EMBO JOURNAL, 1990, 9 (06) :1897-1906
[4]  
Alvarez JD, 2000, GENE DEV, V14, P521
[5]   Repression of the mouse M-lysozyme gene involves both hindrance of enhancer factor binding to the methylated enhancer and histone deacetylation [J].
Ammerpohl, O ;
Schmitz, A ;
Steinmüller, L ;
Renkawitz, R .
NUCLEIC ACIDS RESEARCH, 1998, 26 (23) :5256-5260
[6]   Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent [J].
Anderson, KL ;
Smith, KA ;
Pio, F ;
Torbett, BE ;
Maki, RA .
BLOOD, 1998, 92 (05) :1576-1585
[7]  
ANDRES V, 1992, DEVELOPMENT, V116, P321
[8]   AN OLIGOMER COMPLEMENTARY TO C-MYB-ENCODED MESSENGER-RNA INHIBITS PROLIFERATION OF HUMAN MYELOID-LEUKEMIA CELL-LINES [J].
ANFOSSI, G ;
GEWIRTZ, AM ;
CALABRETTA, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3379-3383
[9]   Structural and functional characterization of the human CD36 gene promoter - Identification of a proximal PEBP2/CBF site [J].
Armesilla, AL ;
Calvo, D ;
Vega, MA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (13) :7781-7787
[10]  
BAE SC, 1993, ONCOGENE, V8, P809