uPAR: A versatile signalling orchestrator

被引：1097

作者：

Blasi, F

Carmeliet, P

机构：

[1] Univ Vita Salute San Raffaele, Dept Mol Biol & Funct Genom, DIBIT, I-20132 Milan, Italy

[2] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 12期

关键词：

D O I：

10.1038/nrm977

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.

引用

收藏

页码：932 / 943

页数：12

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