DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism

被引：8

作者：

Azzam, Eman Zaki ^{[1
]}

Ata, Mohamed Nabil ^{[1
]}

Younan, Doreen Nazeih ^{[2
]}

Salem, Tarek M. ^{[1
]}

Abdul-Aziz, Ahmed Alaa ^{[1
]}

机构：

[1] Univ Alexandria, Fac Med, Endocrinol Unit, Dept Internal Med, Alexandria, Egypt

[2] Univ Alexandria, Fac Med, Dept Chem & Clin Pathol, Alexandria, Egypt

来源：

JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY | 2019年 / 17卷

关键词：

Vitamin D; Obesity; Sclerostin; Bone metabolism; Insulin resistance; GROWTH-FACTOR; 23; BODY-MASS INDEX; PARATHYROID-HORMONE; INSULIN-RESISTANCE; POSTMENOPAUSAL WOMEN; MINERAL DENSITY; FRACTURE RISK; INFLAMMATION; PREVALENCE; EXPRESSION;

D O I：

10.1016/j.jcte.2019.100197

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Aim: To study the relationship between obesity, insulin resistance, vitamin D deficiency and sclerostin as a bone biomarker. Materials and methods: Cross-section study of 75 subjects grouped into 3 groups; obese (n = 31), overweight (n = 23) and normal (n = 21) subjects. Sclerostin, fasting insulin, fasting plasma glucose and 25(OH)D were measured and anthropometric measures were taken. Results: 25(OH)D was lower in obese subjects than overweight and control groups (mean +/- SD 5.27 +/- 5.14 vs. 12.55 +/- 6.99 vs.17.65 +/- 4.07 ng/L, p < 0.001). Sclerostin was significantly lower in obese subjects versus the control (mean +/- SD 1.02 +/- 0.45 vs 1.58 +/- 0.83 ng/mL, p = 0.014). Conclusion: These results lead us to hypothesize that the relationship between sclerostin and Vitamin D levels has an important role in the link between obesity and bone metabolism. DObesity could be an active focus of research in the coming years.

引用

页数：6

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