New strategies in the treatment of graft-versus-host disease

被引：12

作者：

Basara, N ^{[1
]}

Blau, IW ^{[1
]}

Willenbacher, W ^{[1
]}

Kiehl, MG ^{[1
]}

Fauser, AA ^{[1
]}

机构：

[1] Clin Bone Marrow Transplantat & Hematol Oncol, D-55743 Idar Oberstein, Germany

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 25卷 / Suppl 2期

关键词：

mycophenolate mofetil; GVHD; hemopoietic stem cell transplantation;

D O I：

10.1038/sj.bmt.1702345

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

GVHD continues to be a major complication after allogeneic hematopoietic stem cell transplantation even when the recipient is given immunosuppression for the prophylaxis of this severe disease. There have been many advances in the prevention and treatment of GVHD, using compounds such as cyclosporine, FK506, mycophenolate mofetil or monoclonal IL-2 receptor antagonist. New strategies seem to include sequential therapy involving the blocking of both endogenous cytokines and alloreactive donor cells. However, further clinical and laboratory studies are needed in order to improve the therapy of established GVHD.

引用

页码：S12 / S15

页数：4

共 28 条

[1] EFFECT OF HLA INCOMPATIBILITY IN MARROW TRANSPLANTATION FROM UNRELATED AND HLA-MISMATCHED RELATED DONORS [J].

ANASETTI, C ;

HANSEN, JA .

TRANSFUSION SCIENCE, 1994, 15 (03) :221-230

[2]

[Anonymous], 1999, Hematopoietic stem cell transplantation

[3] PHOTOTHERAPY IN THE TREATMENT OF CUTANEOUS GRAFT-VERSUS-HOST DISEASE - OUR PRELIMINARY EXPERIENCE IN RESISTANT PATIENTS [J].

AUBIN, F ;

BRION, A ;

DECONINCK, E ;

PLOUVIER, E ;

HERVE, P ;

HUMBERT, P ;

CAHN, JY .

TRANSPLANTATION, 1995, 59 (01) :151-155

[4] Efficacy and safety of mycophenolate mofetil for the treatment of acute and chronic GVHD in bone marrow transplant recipient [J].

Basara, N ;

Blau, WI ;

Kiehl, MG ;

Römer, E ;

Rudolphi, M ;

Bischoff, M ;

Kirsten, D ;

Sanchez, H ;

Günzelmann, S ;

Fauser, AA .

TRANSPLANTATION PROCEEDINGS, 1998, 30 (08) :4087-4089

[5] Mycophenolate mofetil for the treatment of acute and chronic GVHD in bone marrow transplant patients [J].

Basara, N ;

Blau, WI ;

Römer, E ;

Rudolphi, M ;

Bischoff, M ;

Kirsten, D ;

Sanchez, H ;

Günzelmann, S ;

Fauser, AA .

BONE MARROW TRANSPLANTATION, 1998, 22 (01) :61-65

[6] TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE WITH METHYLPREDNISOLONE AND CYCLOSPORINE WITH OR WITHOUT AN ANTI-INTERLEUKIN-2 RECEPTOR MONOCLONAL-ANTIBODY - A MULTICENTER PHASE-III STUDY [J].

CAHN, JY ;

BORDIGONI, P ;

TIBERGHIEN, P ;

MILPIED, N ;

BRION, A ;

WIDJENES, J ;

LIOURE, B ;

MICHEL, G ;

BURDACH, S ;

KOLB, HJ ;

LINK, H ;

VERNANT, JP ;

IFRAH, N ;

RACADOT, E ;

HERVE, P ;

EHNINGER, G .

TRANSPLANTATION, 1995, 60 (09) :939-942

[7]

FERRARA JLM, 1999, HEMATOPOIETIC CELL T, P305

[8] The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection [J].

Graubert, TA ;

Russell, JH ;

Ley, TJ .

BLOOD, 1996, 87 (04) :1232-1237

[9] Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease [J].

Greinix, HT ;

Volc-Platzer, B ;

Rabitsch, W ;

Gmeinhart, B ;

Guevara-Pineda, C ;

Kalhs, P ;

Krutmann, J ;

Hönigsmann, H ;

Ciovica, M ;

Knobler, RM .

BLOOD, 1998, 92 (09) :3098-3104

[10]

HEBART H, 1999, BONE MARROW TRANSPAN, V23, pA301

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