Qiliqiangxin regulates the balance between tumor necrosis factor-α and interleukin-10 and improves cardiac function in rats with myocardial infarction

被引：82

作者：

Xiao, Hong ^{[1
,2
]}

Song, You ^{[1
]}

Li, Ya ^{[1
]}

Liao, Yu-hua ^{[1
]}

Chen, Jian ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Lab Cardiovasc Immunol, Inst Cardiol, Union Hosp,Tongji Med Coll, Wuhan 430022, Peoples R China

[2] NO1 Hosp Wuhan, Wuhan 430030, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2009年 / 260卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Qiliqiangxin; Myocardial infarction; Cytokine; Tumor necrosis factor-alpha; Interleukin-10; HEART-FAILURE; INFLAMMATION; HERB;

D O I：

10.1016/j.cellimm.2009.09.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The study investigated the effects of traditional Chinese drug Qiliqiangxin on cardiac function and the expression of pro/anti-inflammatory cytokines TNF-alpha/IL-10 in rats with myocardial infarction (MI). Rats with MI were randomly divided into drug-treated group (MI-Q) and control group (MI-C) compared with sham-operated group (S). Rats in the MI-Q group were treated with crude drug of oral Qiliqiangxin 24 h after operation at the dosage of 4 g/kg/day for 4 weeks, while in MI-C group and S group were treated with normal saline at the same time. Echocardiography and hemodynamic parameters, histopathologic changes and the expression of myocardial cytokines including TNF-alpha and IL-10 were assessed 4 weeks after the drug therapy. The results indicated that rats of the MI-C group exhibited decreased cardiac function and increased ratio of TNF-alpha/IL-10 which principally secreted by myocardium compared with those of the S group and Qiliqiangxin treatment significantly improved cardiac function and histopathologic changes with down-regulated ratio of TNF-alpha/IL-10. These data suggests that Qiliqiangxin may improve cardiac function of rats with MI through regulation the balance between TNF-alpha and IL-10. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：51 / 55

页数：5

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