Enhancing effect of 5 α-cyprinol sulfate on mucosal membrane permeability to sodium ampicillin in rats

被引：5

作者：

Murakami, T ^{[1
]}

Ohoku, K ^{[1
]}

Yumoto, R ^{[1
]}

Yoshii, M ^{[1
]}

Une, M ^{[1
]}

Kuramoto, T ^{[1
]}

Hoshita, T ^{[1
]}

Yata, N ^{[1
]}

机构：

[1] Hiroshima Univ, Fac Med, Inst Pharmaceut Sci, Minami Ku, Hiroshima 7348551, Japan

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2000年 / 49卷 / 02期

关键词：

bile alcohol; 5 alpha-cyprinol sulfate; membrane permeability; sodium ampicillin; physiochemical property;

D O I：

10.1016/S0939-6411(99)00083-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effect of 5 alpha-cyprinol sulfate, a bile alcohol sulfate specific to carp bile, on rectal membrane permeability to sodium ampicillin (AMP Na) was examined in rats. AMP Na is not easily absorbed through rat rectal membrane without aid. 5 alpha-Cyprinol sulfate significantly enhanced the rectal membrane permeability to AMP Na even at a low concentration (6.25 mM), though sodium taurocholate needed a higher concentration (25 mM). Co-administration of phosphatidylcholine significantly suppressed the enhancing action of both sodium taurocholate and 5 alpha-cyprinol sulfate. On the other hand, calcium ion did not suppress the action of 5 alpha-cyprinol sulfate, although it did clearly suppress the action of sodium taurocholate. In conclusion, 5 alpha-cyprinol sulfate was found to have a potent enhancing effect on mucosal membrane permeability to water-soluble compounds. The enhancing mechanism of 5 alpha-cyprinol sulfate appeared to be different from that of sodium taurocholate. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：111 / 117

页数：7

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