Emotional memory and psychopathology

被引:85
作者
Ledoux, JE [1 ]
Muller, J [1 ]
机构
[1] CUNY,CITY COLL,CLIN PSYCHOL PROGRAM,NEW YORK,NY 10021
关键词
D O I
10.1098/rstb.1997.0154
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A leading model for studying how the brain farms memories about unpleasant experiences is fear conditioning. A cumulative body of work has identified major components of the neural system mediating this form of learning. The pathways involve transmission of sensory information from processing areas in the thalamus and cortex to the amygdala. The amygdala's lateral nucleus receives and integrates the sensory inputs from the thalamic and cortical areas, and the central nucleus provides the interface with motor systems controlling specific fear responses in various modalities (behavioural, autonomic, endocrine). Internal connections within the amygdala allow the lateral and central nuclei to communicate. Recent studies have begun to identify some sites of plasticity in the circuitry and the cellular mechanisms involved in fear conditioning. Through studies of fear conditioning, our understanding of emotional memory is being taken to the level of cells and synapses in the brain. Advances in understanding emotional memory hold out the possibility that emotional disorders may be better defined and treatment improved.
引用
收藏
页码:1719 / 1726
页数:8
相关论文
共 76 条
[1]   Stimulus generalization of fear responses: Effects of auditory cortex lesions in a computational model and in rats [J].
Armony, JL ;
ServanSchreiber, D ;
Romanski, LM ;
Cohen, JD ;
LeDoux, JE .
CEREBRAL CORTEX, 1997, 7 (02) :157-165
[2]   DOUBLE DISSOCIATION OF CONDITIONING AND DECLARATIVE KNOWLEDGE RELATIVE TO THE AMYGDALA AND HIPPOCAMPUS IN HUMANS [J].
BECHARA, A ;
TRANEL, D ;
DAMASIO, H ;
ADOLPHS, R ;
ROCKLAND, C ;
DAMASIO, AR .
SCIENCE, 1995, 269 (5227) :1115-1118
[3]   PASSIVE AND ACTIVE REACTIONS TO FEAR-ELICITING STIMULI [J].
BLANCHAR.RJ ;
BLANCHAR.DC .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1969, 68 (1P1) :129-&
[4]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[5]   A PERCEPTUAL-DEFENSIVE-RECUPERATIVE MODEL OF FEAR AND PAIN [J].
BOLLES, RC ;
FANSELOW, MS .
BEHAVIORAL AND BRAIN SCIENCES, 1980, 3 (02) :291-301
[6]   RESPONSE PROPERTIES OF SINGLE UNITS IN AREAS OF RAT AUDITORY THALAMUS THAT PROJECT TO THE AMYGDALA .1. ACOUSTIC DISCHARGE PATTERNS AND FREQUENCY RECEPTIVE-FIELDS [J].
BORDI, F ;
LEDOUX, JE .
EXPERIMENTAL BRAIN RESEARCH, 1994, 98 (02) :261-274
[7]  
BORDI F, 1992, J NEUROSCI, V12, P2493
[8]   RESPONSE PROPERTIES OF SINGLE UNITS IN AREAS OF RAT AUDITORY THALAMUS THAT PROJECT TO THE AMYGDALA .2. CELLS RECEIVING CONVERGENT AUDITORY AND SOMATOSENSORY INPUTS AND CELLS ANTIDROMICALLY ACTIVATED BY AMYGDALA STIMULATION [J].
BORDI, F ;
LEDOUX, JE .
EXPERIMENTAL BRAIN RESEARCH, 1994, 98 (02) :275-286
[9]   CONDITIONED FEAR ASSESSED BY FREEZING AND BY THE SUPPRESSION OF 3 DIFFERENT BASELINES [J].
BOUTON, ME ;
BOLLES, RC .
ANIMAL LEARNING & BEHAVIOR, 1980, 8 (03) :429-434
[10]   A FURTHER DEMONSTRATION OF THE EFFECTS OF ELECTRO-CONVULSIVE SHOCK ON A CONDITIONED EMOTIONAL RESPONSE [J].
BRADY, JV ;
HUNT, HF .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1951, 44 (03) :204-209