Regulation of NF-κB activity through lysine monomethylation of p65

被引：188

作者：

Ea, Chee-Kwee ^{[1
]}

Baltimore, David ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 45期

关键词：

methylation; SET9; HISTONE H3; P53; ACTIVITY; METHYLATION; METHYLTRANSFERASE; TRANSCRIPTION; ACETYLATION; ACTIVATION; SUBUNIT; SET7/9;

D O I：

10.1073/pnas.0910439106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

NF-kappa B is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-kappa B is regulated by different posttranslational modifications. Here, we report a novel mechanism of NF-kappa B regulation through lysine monomethylation by SET9 methyltransferase. Set9 specifically methylates p65 at lysine 37. Both TNF alpha and IL-1 beta treatments induced methylation of p65. Methylated p65 is restricted to the nucleus and this modification regulates the promoter binding of p65. Moreover, Set9 mediated methylation of p65 is required for the expression of a subset of NF-kappa B target genes in response to TNF alpha stimulation.

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收藏

页码：18972 / 18977

页数：6

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