The first 30 years of p53: growing ever more complex

被引：1438

作者：

Levine, Arnold J. ^{[1
]}

Oren, Moshe ^{[2
]}

机构：

[1] Inst Adv Study, Sch Nat Sci, Princeton, NJ 08540 USA

[2] Weizmann Inst Sci, IL-76100 Rehovot, Israel

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

WILD-TYPE P53; CELLULAR TUMOR-ANTIGEN; SINGLE NUCLEOTIDE POLYMORPHISM; AUTOREGULATORY FEEDBACK LOOP; AMINO-ACID-SEQUENCE; SUPPRESSOR P53; MUTANT P53; TRANSCRIPTIONAL ACTIVATION; SV40-TRANSFORMED CELLS; GENE-EXPRESSION;

D O I：

10.1038/nrc2723

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen, the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53 DNA and the realization that p53 is not an oncogene but a tumour suppressor that is very frequently mutated in human cancer. In the second decade of research, the function of p53 was uncovered: it is a transcription factor induced by stress, which can promote cell cycle arrest, apoptosis and senescence. In the third decade after its discovery new functions of this protein were revealed, including the regulation of metabolic pathways and cytokines that are required for embryo implantation. The fourth decade of research may see new p53-based drugs to treat cancer. What is next is anybody's guess.

引用

页码：749 / 758

页数：10

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