[Bis(2-pyridyldimethylsilyl)methyl]lithium. New reagent for the stereoselective synthesis of vinylsilanes

被引：42

作者：

Itami, K ^{[1
]}

Nokami, T ^{[1
]}

Yoshida, J ^{[1
]}

机构：

[1] Kyoto Univ, Dept Synth Chem & Biol Chem, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1021/ol005735n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The generation of (2-PyMe2Si)(2)CHLi was easily accomplished by the deprotonation of (2-PyMe2Si)(2)CH2 using n-BuLi in Et2O. Thus generated (2-PyMe2Si)(2)CHLi was found to react with a variety of aldehydes and ketones to give the corresponding vinylsilanes in extremely high yields with complete stereoselectivities.

引用

页码：1299 / 1302

页数：4

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