Role of ethanol in the regulation of hepatic stellate cell function

被引：62

作者：

Wang, Jian-Hua ^{[1
]}

Batey, Robert G.

George, Jacob

机构：

[1] Univ Sydney, Westmead Millennium Inst, Storr Liver Unit, Westmead, NSW 2145, Australia

[2] Westmead Hosp, Westmead, NSW 2145, Australia

[3] Hunter New England Area Hlth Serv, Drug & Alcohol Clin Serv, Wallsend 2287, Tyne & Wear, England

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 43期

关键词：

ethanol; acetaldehyde; hepatic stellate cells; liver fibrosis; type I collagen gene; transcription factors; transforming growth factor beta-1;

D O I：

10.3748/wjg.v12.i43.6926

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Evidence has accumulated to suggest an important role of ethanol and/or its metabolites in the pathogenesis of alcohol-related liver disease. In this review, the fibrogenic effects of ethanol and its metabolites on hepatic stellate cells (HSCs) are discussed. In brief, ethanol interferes with retinoid metabolism and its signaling, induces the release of fibrogenic cytokines such as transforming growth factor beta-1 (TGF beta-1) from HSCs, up-regulates the gene expression of collagen I and enhances type I collagen protein production by HSCs. Ethanol further perpetuates an activated HSC phenotype through extracellular matrix remodeling. The underlying pathophysiologic mechanisms by which ethanol exerts these pro-fibrogenic effects on HSCs are reviewed. (c) 2006 The WJG Press. All rights reserved.

引用

页码：6926 / 6932

页数：7

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