The schizophrenic faces of PICK1

被引：42

作者：

Dev, Kumlesh K.

Henley, Jeremy M.

机构：

[1] Novartis Pharmaceut, Novartis Inst Biomed Res, Neurosci Res, CH-4056 Basel, Switzerland

[2] Univ Bristol, Sch Med Sci, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 11期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.tips.2006.09.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene. Here, we outline possible molecular mechanisms, discuss clinical case-studies that indicate an unexpected role of PICK1 in schizophrenia and discuss potential avenues for pharmacological manipulation of PICK1.

引用

页码：574 / 579

页数：6

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