Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

被引：34

作者：

Buechner, Frederike L. ^{[1
,2
]}

Bueno-de-Mesquita, H. Bas ^{[1
]}

Ros, Martine M. ^{[1
,2
]}

Kampman, Ellen ^{[2
]}

Egevad, Lars ^{[3
]}

Overvad, Kim ^{[4
]}

Raaschou-Nielsen, Ole ^{[5
]}

Tjonneland, Anne ^{[5
]}

Roswall, Nina ^{[5
]}

Clavel-Chapelon, Francoise ^{[6
,7
]}

Boutron-Ruault, Marie-Christine ^{[6
,7
]}

Touillaud, Marina ^{[6
,7
]}

Chang-Claude, Jenny ^{[8
]}

Kaaks, Rudolf ^{[8
]}

Boeing, Heiner ^{[9
]}

Weikert, Steffen ^{[9
,10
]}

Trichopoulou, Antonia ^{[11
,12
]}

Lagiou, Pagona ^{[11
]}

Trichopoulos, Dimitrios ^{[13
]}

Palli, Domenico ^{[14
]}

Sieri, Sabina ^{[15
]}

Vineis, Paolo ^{[16
,17
]}

Tumino, Rosario ^{[18
,19
]}

Panico, Salvatore ^{[20
]}

Vrieling, Alina

Peeters, Petra H. M. ^{[21
]}

van Gils, Carla H. ^{[21
]}

Lund, Eiliv ^{[22
]}

Gram, Inger T. ^{[22
]}

Engeset, Dagrun ^{[22
]}

Martinez, Carmen ^{[23
]}

Gonzalez, Carlos A. ^{[24
]}

Larranaga, Nerea ^{[25
]}

Ardanaz, Eva ^{[26
,27
]}

Navarro, Carmen ^{[26
,27
]}

Rodriguez, Laudina ^{[28
]}

Manjer, Jonas ^{[29
]}

Ehrnstrom, Roy A. ^{[30
]}

Hallmans, Goran ^{[31
]}

Ljungberg, Borje ^{[32
]}

Allen, Naomi E. ^{[33
]}

Roddam, Andrew W. ^{[33
]}

Bingham, Sheila ^{[34
]}

Khaw, Kay-Tee ^{[35
]}

Slimani, Nadia ^{[36
]}

Boffetta, Paolo ^{[36
]}

Jenab, Mazda ^{[36
]}

Mouw, Traci ^{[17
]}

Michaud, Dominique S. ^{[17
]}

Kiemeney, Lambertus A. L. M. ^{[2
,37
,38
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands

[3] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden

[4] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] INSERM, ERI 20, EA 4045, F-75654 Paris 13, France

[7] Inst Cancerol Gustave Roussy, Villejuif, France

[8] Deutsch Krebsforschungszentrum, Div Clin Epidemiol, D-6900 Heidelberg, Germany

[9] German Inst Human Nutr, Potsdam, Germany

[10] Charite, Dept Urol, D-13353 Berlin, Germany

[11] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-10679 Athens, Greece

[12] Hellenic Hlth Fdn, Athens, Greece

[13] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[15] Ist Nazl Tumori, Fdn IRCCS, Nutr Epidemiol Unit, I-20133 Milan, Italy

[16] Univ Turin, Dept Canc Epidemiol, Turin, Italy

[17] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

[18] Civile MP Arezzo Hosp, Cancer Registry, Ragusa, Italy

[19] Civile MP Arezzo Hosp, Dept Oncol, Histopathol Unit, Ragusa, Italy

[20] Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, Naples, Italy

[21] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[22] Univ Tromso, Inst Community Med, Tromso, Norway

[23] Andalusian Sch Publ Hlth, Granada, Spain

[24] ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[25] Basque Govt, Publ Hlth Dept Gipuzkoa, Gipuzkoa, Spain

[26] Publ Hlth Inst Navarra, Pamplona, Spain

[27] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[28] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[29] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[30] Malmo Univ Hosp, Dept Pathol, Malmo, Sweden

[31] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[32] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[33] Univ Oxford, Canc Res UK Epidemiol Unit, Oxford, England

[34] MRC, Dunn Human Nutr Unit, Cambridge, England

[35] Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge, England

[36] Int Agcy Res Canc, F-69372 Lyon, France

[37] Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands

[38] Comprehens Canc Ctr E, Nijmegen, Netherlands

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 125卷 / 11期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

bladder cancer; fruit; vegetables; EPIC; VITAMIN-C; CIGARETTE-SMOKING; PROSPECTIVE COHORT; CAROTENOIDS; EPIDEMIOLOGY; FOLATE; DIET; FOOD;

D O I：

10.1002/ijc.24582

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow-up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow-up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95-1.01). Borderline statistically significant lower bladder cancer risks were found among fever smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87-1.00 with increments of 100 g/day; calibrate HR = 0.92 95%CI 0.79-1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82-0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk. (c) 2009 UICC

引用

页码：2643 / 2651

页数：9

共 36 条

[1] Consumption of vegetables, fruit and other plant foods in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts from 10 European countries [J].

Agudo, A ;

Slimani, N ;

Ocké, MC ;

Naska, A ;

Miller, AB ;

Kroke, A ;

Bamia, C ;

Karalis, D ;

Vineis, P ;

Palli, D ;

Bueno-de-Mesquita, HB ;

Peeters, PHM ;

Engeset, D ;

Hjartåker, A ;

Navarro, C ;

Garcia, CM ;

Wallström, P ;

Zhang, JX ;

Welch, AA ;

Spencer, E ;

Stripp, C ;

Overvad, K ;

Clavel-Chapelon, F ;

Casagrande, C ;

Riboli, E .

PUBLIC HEALTH NUTRITION, 2002, 5 (6B) :1179-1196

[2]

[Anonymous], 2007, FOOD NUTR PHYS ACT P

[3]

BJERREGAARD BK, 2006, INT J CANCER, V119, P2142

[4]

Brennan P, 2000, INT J CANCER, V86, P289, DOI 10.1002/(SICI)1097-0215(20000415)86:2<289::AID-IJC21>3.0.CO

[5]

2-M

[6] The contribution of cigarette smoking to bladder cancer in women (pooled European data) [J].

Brennan, P ;

Bogillot, O ;

Greiser, E ;

Chang-Claude, J ;

Wahrendorf, J ;

Cordier, S ;

Jöckel, KH ;

Lopez-Abente, G ;

Tzonou, A ;

Vineis, P ;

Donato, F ;

Hours, M ;

Serra, C ;

Bolm-Audorff, U ;

Schill, W ;

Kogevinas, M ;

Boffetta, P .

CANCER CAUSES & CONTROL, 2001, 12 (05) :411-417

[7] Carotenoids/vitamin C and smoking-related bladder cancer [J].

Castelao, JE ;

Yuan, JM ;

Gago-Dominguez, M ;

Skipper, PL ;

Tannenbaum, SR ;

Chan, KK ;

Watson, MA ;

Bell, DA ;

Coetzee, GA ;

Ross, RK ;

Yu, MC .

INTERNATIONAL JOURNAL OF CANCER, 2004, 110 (03) :417-423

[8] Epidemiology and etiology of premalignant and malignant urothelial changes [J].

Cohen, SM ;

Shirai, T ;

Steineck, G .

SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 2000, 34 :105-115

[9]

Curado M.P., 2007, IARC Scientific Publication, V160

[10] Estimates of the cancer incidence and mortality in Europe in 2006 [J].

Ferlay, J. ;

Autier, P. ;

Boniol, M. ;

Heanue, M. ;

Colombet, M. ;

Boyle, P. .

ANNALS OF ONCOLOGY, 2007, 18 (03) :581-592

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