Hijacking the Chromatin Remodeling Machinery: Impact of SWI/SNF Perturbations in Cancer

被引：93

作者：

Weissman, Bernard ^{[3
,4
]}

Knudsen, Karen E. ^{[1
,2
]}

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Urol, Dept Canc Biol, Philadelphia, PA 19107 USA

[3] Univ N Carolina, Dept Pathol & Lab, Chapel Hill, NC USA

[4] Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 21期

关键词：

TUMOR-SUPPRESSOR GENE; HUMAN LUNG-CANCER; ATYPICAL TERATOID/RHABDOID TUMORS; MALIGNANT RHABDOID TUMORS; CELL-LINES; PROSTATE-CANCER; BREAST-CANCER; PROTEIN EXPRESSION; SOMATIC MUTATIONS; GERMLINE MUTATION;

D O I：

10.1158/0008-5472.CAN-09-2166

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10 to 12 unique subunits. Although the biochemical consequence of SWI/SNF in model systems has been extensively reviewed, the present article focuses on the evidence linking SWI/SNF perturbations to cancer initiation and tumor progression in human disease. [Cancer Res 2009;69(2.1):8223-30]

引用

页码：8223 / 8230

页数：8

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