Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

被引：259

作者：

Effros, RB ^{[1
]}

Pawelec, G ^{[1
]}

机构：

[1] UNIV TUBINGEN,SCH MED,DEPT INTERNAL MED 2,SECT TRANSPLANTAT IMMUNOL,D-72076 TUBINGEN,GERMANY

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(97)01079-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.

引用

页码：450 / 454

页数：5

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