Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

被引：484

作者：

Earley, CJ

Connor, JR

Beard, JL

Malecki, EA

Epstein, DK

Allen, RP

机构：

[1] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA

[2] Penn State Univ, Milton S Hershey Med Ctr, Dept Anat & Neurosci, University Pk, PA 16802 USA

[3] Penn State Univ, Dept Nutr, University Pk, PA 16802 USA

[4] Penn State Univ, State Coll, PA USA

来源：

NEUROLOGY | 2000年 / 54卷 / 08期

关键词：

restless legs syndrome; iron; ferritin; transferrin-CSF;

D O I：

10.1212/WNL.54.8.1698

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1.11 +/- 0.25 ng/mL versus 3.50 +/- 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 +/- 5.1 mg/L versus 6.71 +/- 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.

引用

页码：1698 / 1700

页数：3

共 10 条

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NUTRITIONAL IRON AND DOPAMINE BINDING-SITES IN THE RAT-BRAIN [J].