Severe hepatotoxicity on beginning propylthiouracil therapy

被引：14

作者：

Lock, DR ^{[1
]}

Sthoeger, ZM ^{[1
]}

机构：

[1] KAPLAN HOSP,DEPT INTERNAL MED B,IL-76100 REHOVOT,ISRAEL

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 1997年 / 24卷 / 04期

关键词：

propylthiouracil; drug-induced hepatotoxicity; reversible prolonged PTU-induced hepatotoxicity;

D O I：

10.1097/00004836-199706000-00020

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report a case of propylthiouracil (PTU)-induced cholestatic hepatotoxicity in Graves' disease that developed 1 day after beginning PTU. After clinical recovery, liver abnormalities persisted for 5 years. Percutaneous liver biopsy and the eventual normalization of enzyme levels excluded permanent liver damage as a result of PTU therapy. Thus prolonged elevation of serum enzymes is consistent with the diagnosis of PTU-induced hepatotoxicity, which may recover completely.

引用

页码：267 / 269

页数：3

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