Effect of chain length on transfection properties of spermine-based gemini surfactants

被引：25

作者：

Castro, M

Griffiths, D

Patel, A

Pattrick, N

Kitson, C

Ladlow, M

机构：

[1] Univ Cambridge, Chem Lab, GlaxoSmithKline Cambridge Technol Ctr, Cambridge CB2 1EW, England

[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 19期

关键词：

D O I：

10.1039/b410240a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and associated structure - activity relationships for gene transfection of a series of spermine-derived cationic gemini surfactants incorporating diamino acid headgroups and either identical ( symmetrical) or different ( unsymmetrical) lipophilic tailgroups is described. Transfection activity is found to depend critically upon the structural elements present.

引用

收藏

页码：2814 / 2820

页数：7

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