Brain injury after intracerebral hemorrhage - The role of thrombin and iron

被引：224

作者：

Hua, Ya ^{[1
]}

Keep, Richard F. ^{[1
]}

Hoff, Julian T. ^{[1
]}

Xi, Guohua ^{[1
]}

机构：

[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

来源：

STROKE | 2007年 / 38卷 / 02期

关键词：

brain edema; cerebral hemorrhage; iron; thrombin;

D O I：

10.1161/01.STR.0000247868.97078.10

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intracerebral hemorrhage (ICH) is a subtype of stroke with high morbidity and mortality. The mechanisms underlying ICH-induced brain injury have become better understood during the past decade. Experimental investigations have indicated that thrombin formation, red blood cell lysis, and iron toxicity play a major role in ICH-induced injury and that these mechanisms may provide new therapeutic targets. This article reviews the role of thrombin and iron in ICH-induced injury. (Stroke. 2007;38[part 2]:759-762.)

引用

收藏

页码：759 / 762

页数：4

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