Molecular Regulation of Vertebrate Retina Cell Fate

被引：32

作者：

Andreazzoli, Massimiliano ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Biol, Sez Biol Cellulare & Sviluppo, I-56010 Pisa, Italy

来源：

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS | 2009年 / 87卷 / 03期

关键词：

eye; cell fate; transcription factors; growth factors; miRNAs; stem cells; INTERKINETIC NUCLEAR MIGRATION; XRX1 CONTROLS PROLIFERATION; RNA-BINDING PROTEIN; HOMEOBOX GENE; GANGLION-CELL; TRANSCRIPTION FACTORS; PROGENITOR CELLS; MULLER GLIA; STEM-CELLS; C-ELEGANS;

D O I：

10.1002/bdrc.20161

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The specification of retinal cell fate is a multistep process that begins during early development and results from the spatio-temporal coordination of cell cycle, cell differentiation, and morphogenesis. This review focuses on recent advances in understanding the molecular mechanisms underlying the distinct steps of retinal specification. Emphasis is placed on key regulatory events that control the multipotency of retinal progenitors, the generation of cell diversity, and the establishment of the clock that determines the ordered generation of retinal cell types. These basic studies have paved the way to the latest progress on the isolation and in vitro generation of retinal stem cells, which is presented in the light of possible therapeutic applications. Birth Defects Research (Part C) 87:284-295, 2009. (C) 2009 Wiley-Liss, Inc.

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页码：284 / 295

页数：12

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