Dose dependent effects of yohimbine on methadone maintained patients

被引：14

作者：

Hameedi, FA

Woods, SW

Rosen, MI

Pearsall, HR

Kosten, TR

机构：

[1] Medication Development Research Center, Department of Psychiatry, Yale School of Medicine, New Haven, CT

[2] Medication Development Research Center, New Haven, CT 06519

来源：

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE | 1997年 / 23卷 / 02期

关键词：

methadone maintenance; opiate withdrawal; treatment; yohimbine;

D O I：

10.3109/00952999709040950

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Twelve methadone-maintained patients were randomized into a controlled crossover study with active and placebo yohimbine 20 mg once a day (n = 4), 5mg three times a day (n = 4) or 10 mg three times a day (n = 4) for seven days to evaluate the effect of yohimbine on naloxone precipitated opiate withdrawal. The yohimbine dose of 10 mg TID was well tolerated and was associated with an average decrease of 30% in precipitated withdrawal symptoms.

引用

页码：327 / 333

页数：7

共 13 条

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CHARNEY DS, 1987, AM J PSYCHIAT, V144, P1030

[2] YOHIMBINE EXACERBATES AND CLONIDINE ATTENUATES ACUTE MORPHINE WITHDRAWAL IN RATS [J].