Copper(II)-catalyzed aminohydroxylation of olefins

被引：158

作者：

Michaelis, David J. ^{[1
]}

Shaffer, Christopher J. ^{[1
]}

Yoon, Tehshik P. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 07期

关键词：

D O I：

10.1021/ja067894t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a novel copper(II)-catalyzed aminohydroxylation in which both heteroatoms of an N-sulfonyl oxaziridine are added across an alkene in a regioselective fashion. A variety of styrenes and electron-rich alkenes can be aminohydroxylated using this protocol. Preliminary investigations indicate that this new process is a rare non-oxenoid reaction of N-sulfonyl oxaziridines, involving a stepwise, polar mechanism rather than a concerted process.

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页码：1866 / +

页数：3

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