Lipoprotein lipase gene polymorphisms in ischaemic stroke and carotid stenosis

被引：24

作者：

Huang, P ^{[1
]}

Kostulas, K ^{[1
]}

Huang, WX ^{[1
]}

Crisby, M ^{[1
]}

Kostulas, V ^{[1
]}

Hillert, J ^{[1
]}

机构：

[1] HUDDINGE UNIV HOSP, DEPT NEUROL, KAROLINSKA INST, S-14186 HUDDINGE, SWEDEN

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1997年 / 27卷 / 09期

关键词：

carotid stenosis; cerebrovascular disease; genetic susceptibility; hyperlipidaemia; ischaemic stroke; lipoprotein lipase;

D O I：

10.1046/j.1365-2362.1997.1820730.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ischaemic stroke is pathogenetically heterogeneous, but there is strong evidence that genetic as well as environment factors contribute to the risk of the individual. Here we report the similar distribution of polymorphic markers of the lipoprotein lipase (LPL) gene in 128 patients with ischaemic stroke, 56 patients with carotid artery stenosis and 95 healthy control subjects, in spite of a significant influence of the Asn291--> Ser mutation on serum levels of triglycerides. We conclude that these LPL polymorphisms do not contribute greatly to the overall risk of ischaemic stroke in the general population.

引用

页码：740 / 742

页数：3

共 12 条

[1] A STUDY OF TWINS AND STROKE [J].

BRASS, LM ;

ISAACSOHN, JL ;

MERIKANGAS, KR ;

ROBINETTE, CD .

STROKE, 1992, 23 (02) :221-223

[2]

BRUIN T, 1992, NUCLEIC ACIDS RES, V19, P6346

[3]

FISHER RM, 1995, J LIPID RES, V36, P2104

[4] POLYMORPHISMS IN THE LIPOPROTEIN-LIPASE GENE AND THEIR ASSOCIATIONS WITH PLASMA-LIPID CONCENTRATIONS IN 40-YEAR-OLD DANISH MEN [J].

GERDES, C ;

GERDES, LU ;

HANSEN, PS ;

FAERGEMAN, O .

CIRCULATION, 1995, 92 (07) :1765-1769

[5]

JEMAA R, 1995, J LIPID RES, V36, P2141

[6] PCR ASSAY FOR A POLYMORPHIC PVUII SITE IN THE LPL GENE [J].

JOHNSON, JP ;

NISHINA, PM ;

NAGGERT, JK .

NUCLEIC ACIDS RESEARCH, 1990, 18 (24) :7469-7469

[7]

MITCHELL RJ, 1994, HUM BIOL, V66, P383

[8] A LIPOPROTEIN-LIPASE MUTATION (ASN291SER) IS ASSOCIATED WITH REDUCED HDL CHOLESTEROL LEVELS IN PREMATURE ATHEROSCLEROSIS [J].

REYMER, PWA ;

GAGNE, E ;

GROENEMEYER, BE ;

ZHANG, HF ;

FORSYTH, I ;

JANSEN, H ;

SEIDELL, JC ;

KROMHOUT, D ;

LIE, KE ;

KASTELEIN, J ;

HAYDEN, MR .

NATURE GENETICS, 1995, 10 (01) :28-34

[9] Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease [J].

Rubattu, S ;

Volpe, M ;

Kreutz, R ;

Ganten, U ;

Ganten, D ;

Lindpaintner, K .

NATURE GENETICS, 1996, 13 (04) :429-434

[10] GENETIC AND ENVIRONMENTAL-INFLUENCES ON PREMATURE DEATH IN ADULT ADOPTEES [J].

SORENSEN, TIA ;

NIELSEN, GG ;

ANDERSEN, PK ;

TEASDALE, TW .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (12) :727-732

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