C-type lectin receptors orchestrate antifungal immunity

被引：378

作者：

Hardison, Sarah E. ^{[1
]}

Brown, Gordon D. ^{[1
]}

机构：

[1] Univ Aberdeen, Sect Immunol & Infect, Aberdeen Fungal Grp, Aberdeen, Scotland

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 09期

基金：

英国惠康基金;

关键词：

CHRONIC MUCOCUTANEOUS CANDIDIASIS; T-CELL RESPONSES; PATTERN-RECOGNITION RECEPTOR; TOLL-LIKE RECEPTORS; HUMAN DENDRITIC CELLS; HYPER-IGE SYNDROME; NF-KAPPA-B; HOST-DEFENSE; MANNOSE RECEPTOR; FUNGAL-INFECTIONS;

D O I：

10.1038/ni.2369

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this Review, we highlight recent advances in the understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRRs orchestrate antifungal immunity and briefly discuss progress in the use of these receptors as targets for antifungal and other vaccines.

引用

页码：817 / 822

页数：6

共 99 条

[1]

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2]

Chromoblastomycosis: clinical presentation and management [J].

Ameen, M. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2009, 34 (08) :849-854

[3]

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation [J].

Aouadi, Myriam ;

Tesz, Gregory J. ;

Nicoloro, Sarah M. ;

Wang, Mengxi ;

Chouinard, My ;

Soto, Ernesto ;

Ostroff, Gary R. ;

Czech, Michael P. .

NATURE, 2009, 458 (7242) :1180-U116

[4]

A Novel Th Cell Epitope of Candida albicans Mediates Protection from Fungal Infection [J].

Baer, Eva ;

Gadiator, Andre ;

Bastidas, Sonia ;

Roschitzki, Bernd ;

Acha-Orbea, Hans ;

Oxenius, Annette ;

LeibundGut-Landmann, Salome .

JOURNAL OF IMMUNOLOGY, 2012, 188 (11) :5636-5643

[5]

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes [J].

Barrett, Nora A. ;

Rahman, Opu M. ;

Fernandez, James M. ;

Parsons, Matthew W. ;

Xing, Wei ;

Austen, K. Frank ;

Kanaoka, Yoshihide .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (03) :593-604

[6]

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling [J].

Bourgeois, Christelle ;

Majer, Olivia ;

Frohner, Ingrid E. ;

Lesiak-Markowicz, Iwona ;

Hildering, Kwang-Soo ;

Glaser, Walter ;

Stockinger, Silvia ;

Decker, Thomas ;

Akira, Shizuo ;

Mueller, Mathias ;

Kuchler, Karl .

JOURNAL OF IMMUNOLOGY, 2011, 186 (05) :3104-3112

[7]

Dectin-1 mediates the biological effects of β-glucans [J].

Brown, GD ;

Herre, J ;

Williams, DL ;

Willment, JA ;

Marshall, ASJ ;

Gordon, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1119-1124

[8]

Tackling Human Fungal Infections [J].

Brown, Gordon D. ;

Denning, David W. ;

Levitz, Stuart M. .

SCIENCE, 2012, 336 (6082) :647-647

[9]

Innate Antifungal Immunity: The Key Role of Phagocytes [J].

Brown, Gordon D. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :1-21

[10]

Preferential induction of CD4+ T cell responses through in vivo targeting of antigen to dendritic cell-associated C-type lectin-1 [J].

Carter, Robert W. ;

Thompson, Clare ;

Reid, Delyth M. ;

Wong, Simon Y. C. ;

Tough, David F. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (04) :2276-2284

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